Journal article
Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial
AX Garg, M Cuerden, H Aguado, M Amir, EP Belley-Cote, K Bhatt, BM Biccard, FK Borges, M Chan, D Conen, E Duceppe, S Efremov, J Eikelboom, E Fleischmann, L Giovanni, P Gross, R Jayaram, M Kirov, Y Kleinlugtenbelt, A Kurz Show all
Canadian Journal of Kidney Health and Disease | SAGE PUBLICATIONS INC | Published : 2022
Abstract
Background: Most patients who take antihypertensive medications continue taking them on the morning of surgery and during the perioperative period. However, growing evidence suggests this practice may contribute to perioperative hypotension and a higher risk of complications. This protocol describes an acute kidney injury substudy of the Perioperative Ischemic Evaluation-3 (POISE-3) trial, which is testing the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy in patients undergoing noncardiac surgery. Objective: To conduct a substudy of POISE-3 to determine whether a perioperative hypotension-avoidance strategy reduces the risk of acute kidney ..
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Awarded by Kidney Foundation of Canada
Funding Acknowledgements
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Canadian Institutes of Health Research and the Australian National Health and Medical Research Council (NHMRC) provided an operating grant for the main POISE-3 trial. The Kidney Foundation of Canada provided an operating grant for the POISE-3 kidney substudy and additional financial support was provided by the Department of Medicine at Western University. In addition, the authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: F.K.B. holds a McMaster University Department of Medicine Career Research Award; M. C. holds grants from the Australian NHMRC (APP1162362) and the Research Grants Council of Hong Kong, General Research Fund (14104419); P.J.D. was supported by a Tier 1 Canada Research Chair in Perioperative Medicine; A.X.G. was supported by the Dr Adam Linton Chair in Kidney Health Analytics and a Clinician Investigator Salary Award from the Canadian Institutes of Health Research; M.J.M.Z. is funded by a Miguel Servet II research contract from the ISCIII (CP1120/00023), Spain; T.R. is supported by the Medical and Health Research Infrastructure Fund; and P.R. was supported by the Western University Resident Research Fellowship Program. No funding entity had a role in data collection, statistical analysis, manuscript writing, or the decision to publish.